Publications
Basak S., Sakia N., Dougherty L., Guo Z., Wu F., Mindlin F., Lary J.W., Cole J.L., Ding F., & Bowen M.E. “Probing Interdomain Linkers and Protein Supertertiary Structure In Vitro and in Live Cells with Fluorescent Protein Resonance Energy Transfer.” Journal of Molecular Biology 2021 Mar 5;433(5):166793. (PMID: 33388290).
Chen P., Lam K.H., Liu Z., Mindlin F.A., Chen B., Gutierrez C.B., Huang L., Zhang Y., Hamza T., Feng H., Matsui T., Bowen M.E., Perry K., Jin R. “Structure of the full-length Clostridium difficile toxin B.” Nature Structural & Molecular Biology. 2019 Aug;26(8):712-719. (PMID: 31308519)
Choi U.B., Sanabria H., Smirnova T., Bowen M.E., Weninger K.R. “Spontaneous Switching among Conformational Ensembles in Intrinsically Disordered Proteins” Biomolecules. 2019 Mar 22;9(3):114. (PMID: 30909517)
Lam, K.H., Guo, Z., Krez, N., Matsui, T., Perry, K., Weisemann, J., Rummel, A., Bowen, M.E., Jin, R. “A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1.” Nature Communications (2018) Dec 18; 9(1):5367. (PMID:30560862)
Yanez-Orozco, I.S., Levesque B., Ma, J., Wang, B., Spencer, M., Adariani, S.R., Ding, F.*, Bowen, M. E.*, Sanabria, H*.(* co-corresponding authors) “Identifying Weak Interdomain Interactions that Stabilize the Supertertiary Structure of the N-Terminal Tandem PDZ Domains of PSD-95” Nature Communications (2018) Sep 13;9(1):3724. (PMID: 30214057)
Hellenkamp, B., Schmid, S., Doroshenko, O., Opanasyuk, O., Kühnemuth, R., Adariani, S.R., Barth, A., Birkedal, V., Bowen, M. E., Chen, H., Cordes, T., Eilert, T., Fijen, C., Götz, M., Gouridis, G., Gratton, E., Ha, T., Hanke, C.A., Hartmann, A., Hendrix, J., Hildebrandt, L.L., Hohlbein, J., Hübner, C., G., Kallis, E., Kapanidis, A.N., Kim, J., Krainer, G., Lamb, D. C., Lee, N.K., Lemke, E.A., Levesque B., Levitus, M, McCann, J.J., Naredi-Rainer, N., Daniel Nettels, Ngo, T., Qiu, R., Röcker, C., Sanabria, H., Schlierf, M, Schuler B., Seidel, H., Streit, L., Tinnefeld, P., Tyagi, S., Vandenberk, N., Weninger, K.R., Wünsch B., Yanez-Orozco, I.S., Michaelis, J., Seidel, C.A.M., Craggs, T.D., Hugel, T. “Precision and accuracy of single-molecule FRET measurements - a worldwide benchmark study.” Nature Methods (2018) Sep;15(9):669-676. (PMID: 30171252)
Pedersen S.W., Albertsen L, Moran G.E., Levesque B., Pedersen S.B., Bartels L., Wapenaar H., Yei F., Zhang M., Bowen M.E., Strømgaard K. “Site-specific phosphorylation of PSD-95 PDZ domains reveals fine-tuned regulation of protein-protein interactions.” ACS Chem Biol. (2017) Jul 10. (PMID:28692247)
Amin J.B., Salussolia C.L., Chan K., Regan M.C., Dai J., Zhou H.X., Furukawa H., Bowen M.E., Wollmuth L.P. “Divergent roles of a peripheral transmembrane segment in AMPA and NMDA receptors” J Gen Physiol. (2017) Jun 5;149(6):661-680. (PMID:28507080)
Cabail M.Z., Li S., Lemmon E., Bowen M.E., Hubbard S.R., Miller W.T. "The insulin and IGF1 receptor kinase domains are functional dimers in the activated state." Nature Communications (2015) Mar 11;6:6406. (PMID: 25758790)
McCann J.J., Choi U.B., Bowen M.E. "Reconstitution of Multivalent PDZ Domain Binding to the Scaffold Protein PSD-95 Reveals Ternary-Complex Specificity of Combinatorial Inhibition." Structure (2014) Oct 7; 22(10):1458–1466. (PMID: 25220472)
Choi U.B., Kazi R., Stenzoski N., Wollmuth L.P., Uversky V.N., Bowen M.E. “Modulating the Intrinsic Disorder in the Cytoplasmic Domain Alters the Biological Activity of the N-Methyl-D-aspartate-sensitive Glutamate Receptor.” Journal of Biological Chemistry. (2013) Aug 2; 288(31):22506-15. (PMCID: PMC3829338).
McCann J., Zheng, L., Rohrbeck, D., Felekyan, S., Kühnemuth, R., Sutton, R.B., Seidel, C.A.M., Bowen, M.E. “Supertertiary Structure of the Synaptic MAGuK Scaffold Proteins is Conserved” Proceedings of the National Academy of Sciences (2012) Sep 25;109(39):15775-80. (PMCID: PMC3465453).
Choi, U. B., Weninger, K. R., and Bowen, M. E. “Immobilization of Proteins for Single-Molecule Fluorescence Resonance Energy Transfer Measurements of Conformation and Dynamics.” Methods in Molecular Biology: Intrinsically Disordered Protein Analysis (2012) 896:3-20. (PMID: 22821514 )
Salussolia, C. L., Corrales, A, Talukder, I., Kazi, R, .Akgul, G., Bowen, M. and Wollmuth, L. P. "Interaction of the M4 segment with other transmembrane segments is required for surface expression of mammalian AMPA receptors." Journal of Biological Chemistry (2011) Nov 18; 286(46): 40205-18. (PMCID: PMC3220572).
Choi, U.B., Xiao, S., Zheng, L., Bowen, M.E. “Effect of Src Phosphorylation on the Disordered C-Terminal Domain of the NMDA Receptor Subunit GluN2B.” Journal of Biological Chemistry (2011) Aug. 26 286:29904-29912 (PMCID: PMC3191031).
McCann J., Zheng, L., Chiantia, S., Bowen, M.E. “Domain Orientation in the Tandem PDZ Supramodule from PSD-95 is Maintained in the Full-Length Protein” Structure (2011) 19, 810-820. (PMCID: PMC3116789).
Choi, U.B., McCann J., Weninger, K., Bowen, M.E. “Beyond the random coil: stochastic conformational switching in intrinsically disordered proteins.” Structure (2011) Apr 13;19(4):566-76. (PMCID: PMC3075556).
McCann J., Choi, U.B., Zheng, L., Weninger, K., Bowen, M.E. “Optimizing methods to recover absolute FRET efficiency from immobilized single molecules.” Biophysical Journal (2010) Aug 4; 99(3):961-70. (PMCID: PMC2913196).